WP5 - To develop an antigenic cartography map for BTV isolates

Lead Partner: IZSAM


Main objectives

  • Comparison of the antigenic clustering visible on the antigenic map with the phylogenetic analysis of the Seg-2/VP2 nucleotide/protein sequences
  • Analysis of the antigenic proximity of available BTV vaccines with currently circulating BTV strains
  • Assessment of the number of amino acid substitutions of the VP2 protein which are able to cause one unit of antigenic change, equivalent to a 2-fold change in antibody titer.